It’s not always easy for pets to tell us when they’ve had a hard day. Instead, pets often show us through their behavior. Lower levels of stress can include sniffing the ground or scratching. As stress escalates, pets may show panting, pupil dilation, trembling or shaking.

Zylkene can help promote calm and relaxed behavior. You can help by supporting pets with appropriate resources. If your pet is still experiencing stress, your veterinarian may recommend additional measures and/or visiting a board-certified veterinary behaviorist.

No. Zylkene and Zylkene Plus are non-drowsy, non-sedating formulas that help promote a sense of calm without affecting your pet’s personality. Zylkene offers a different active ingredient than most other behavior supplements.

In a study, Zylkene helped cats deal with the stress of transportation as early as 2 days after the start of administration.³ Zylkene is a dog and cat calming supplement that is studied with pets, just like yours!

Zylkene Plus is perfect to use during long-term stressful periods. In a study, Zylkene Plus improved signs of emotional discomfort in 32% of dogs left home alone in just 7 days.⁴ Zylkene Plus is a cat and dog calming supplement that is studied with pets, just like yours!

The classic Zylkene formulation can be used 1-2 days before the event. Some pets may need earlier administration (5-7 days).

For best results, use Zylkene alongside behavior modification and environmental management programs developed in consultation with your veterinarian or a board-certified veterinary behaviorist.

Zylkene Plus promotes relaxation over longer periods (at least 30 days). Use Zylkene Plus 1-2 days before the anticipated period or change in routine. Some pets may need earlier administration (5-7 days).

For best results, use Zylkene Plus alongside behavior modification and environmental management programs developed in consultation with your veterinarian or a board-certified veterinary behaviorist.

Administer Zylkene or Zylkene Plus once daily according to the weight of your pet. Capsules can be administered once daily, whole or opened. Can be given during or after mealtime. Follow the recommended administration on the package, unless otherwise instructed by your veterinarian.

Zylkene is formulated with alpha-casozepine, a natural ingredient derived from bovine hydrolyzed milk protein that has clinically proven calming properties.

Inactive ingredients in Zylkene may include: maltodextrin, hypromellose, magnesium stearate, water, calcium carbonate, food starch-modified, and FD&C blue #1.

Each strength of Zylkene may have slight differences. See the product detail pages for complete ingredients.

Zylkene Plus is formulated with alpha-casozepine and white fish muscle hydrolysate for a sustained calming effect that’s ideal for stressful periods of time or recurring situations.

Inactive ingredients in Zylkene Plus may include: carrageenan, FD&C blue 1, hypromellose, magnesium stearate, maltodextrin, potassium chloride, water, and yellow iron oxide.

Each strength of Zylkene Plus may have slight differences. See product detail pages for complete ingredients.

No. Zylkene and Zylkene Plus are made with a lactose- and preservative-free formula, which makes it a good choice for sensitive pets.