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🎆July 4th Prep: Order Early To Beat The Booms

Protect Their Peace.

Help your pet sleep, play, and snuggle right through the fireworks with the official calming supplement of the Fourth of July!

Up To 22 lbs
Vetoquinol Zylkene Calming Supplement, 75 mg for Small Dogs and Cats, up to 22 lbs

Vetoquinol Zylkene Calming Supplement, 75 mg for Small Dogs and Cats, up to 22 lbs

$17.99
AVAILABLE SIZES
23-65 lbs
Vetoquinol Zylkene Calming Supplement, 225 mg for Medium Dogs and Large Cats, 23-65 lbs

Vetoquinol Zylkene Calming Supplement, 225 mg for Medium Dogs and Large Cats, 23-65 lbs

$24.49
AVAILABLE SIZES
33-132 lbs
Vetoquinol Zylkene Calming Supplement, 450 mg for Large Dogs, 33-132 lbs

Vetoquinol Zylkene Calming Supplement, 450 mg for Large Dogs, 33-132 lbs

$36.99
AVAILABLE SIZES

You've Got Questions. We've Got Answers.

Generally, most pets will struggle with fireworks. Animals have acute senses. For them, every flash and bang can be unexpected and alarming. Common signs of a dog scared of fireworks include panting, shaking, and hiding

The terms “fear,” “anxiety” and “phobia” are often used interchangeably. However, veterinarians may view these as three separate diagnoses.¹

• Fear is a response to a real or perceived threat. This can be a normal response. Fears are considered adaptive, since avoiding or defending dangerous situations helps animals survive.

• Anxiety is a more generalized feeling of apprehension or anticipation of danger from unknown or imagined origins. Anxiety may occur after a fear-inducing event or as a result of unrelated environmental changes that are unpredictable.

• A phobia is a sudden, persistent, and excessive fear of a specific stimulus. For example, a noise phobia is a persistent fear of one or more noises. In these cases, dogs show anticipatory fear even before the noise occurs.

Only your veterinarian or veterinary
behaviorist can diagnose your cat with anxiety or a phobia.

Wondering how to prepare your dog for 4th of July fireworks or how to calm your dog during fireworks? Preparation and planning can go a long way towards preparing your dog. We recommend starting a few weeks before with these five steps.

1. Talk to an expert: It’s a good idea to discuss with your veterinarian any changes you can make in the short term to help your dog cope with fireworks.

2. Build a den: Give dogs their own safe place where they can go when they are uneasy or worried. A den (or crate) is useful all year round but is especially good for the fireworks season.

Allow pets to access the den freely at all times. Do not use it as somewhere to send them as a punishment. Cover the den with a blanket when appropriate to muffle the sounds further.

3. Give them Zylkene®
A supplement like Zylkene is a trusted dog calming supplement for fireworks, offering a non-drowsy option. Start Zylkene at least one week before the event is expected and continue throughout the fireworks season. Zylkene is:

✓ Backed by real-world evidence to help relieve stress without drowsy side effects²,³
✓ Vet recommended to help dogs cope with challenging situations like fireworks, new people, thunderstorms, and more!
✓ Contains alpha-casozepine, a naturally occurring milk protein found in cow’s milk
✓ Made with a lactose- and preservative-free formula

Plus, Zylkene can be used with other supportive calming aids like ThunderShirts®, noise-cancelling headphones, simply playing calming music in the background – like this calming playlist – or other aids that work for your pet.

4. Update their identification: Dogs might try to run away if fireworks go off near them. Just in case, make sure the data linked to their microchips and the information on their tags is up to date so they will be reunited with you more quickly.

5. Walk your dog in the light: If possible, walk dogs when it is still light outside. This reduces the possibility of them being exposed to early celebrations.

If you're asking how to calm your dog during fireworks, these tips can help reduce stress.

• Walk dogs earlier in the day before the fireworks are likely to start.
• Once all pets are inside, make sure all windows, doors, and doggie doors are securely closed.

• Always keep dogs inside the house when fireworks are being set off. Do not take your dog to a fireworks display!

• Pull the curtains and switch on the TV or play calming music to dull the noise from the fireworks.

• Try not to leave your pets by themselves while fireworks are going off.

• Don’t force your dog to come to you, especially if they are in their hiding place or den.

• Don’t react to the fireworks yourself. Dogs can pick up on their owner’s anxiety.

• Play with a toy and see if your pet wants to join in, but don’t force them.

• Ignore unusual behavior, such as panting, shaking, or whining unless your dog comes to you first for reassurance.

• Remain calm and confident. Pets often pick up on their owner’s concern.

• Provide distractions, for example new toys or treats.

• DO NOT punish or get angry with your dog! This will only make them more uneasy.

If left unmanaged, these behaviors may get worse over time, resulting in increasingly undesirable behavior. It can also have the effect of worsening their response to other unexpected loud noises such as door slamming or thunder.

Consult with your veterinarian, or a veterinary behaviorist, to work on a behavior modification treatment plan. Calming supplements like Zylkene Plus can provide a sustained calming effect that is ideal for longer stressful periods of time or recurring situations.

In some cases, veterinarians may recommend behavioral plans or dog anxiety medication for fireworks, alongside supplements that provide relief to dogs showing anxious behavior during fireworks season.

Vetoquinol Zylkene Calming Supplement, 75 mg for Small Dogs and Cats, up to 22 lbs

ACTIVE INGREDIENTS PER CAPSULE (0.255 G):
Hydrolyzed Milk Protein (Bovine): 75 mg Providing Alpha-Casozepine

INACTIVE INGREDIENTS:
Maltodextrin, Hypromellose, Magnesium Stearate, Water, Calcium Carbonate, Food Starch-Modified, FD&C Blue #1


Vetoquinol Zylkene Calming Supplement, 225 mg for Medium Dogs and Large Cats, 23-65 lbs


ACTIVE INGREDIENTS PER CAPSULE (0.250 G):
Hydrolyzed Milk Protein (Bovine): 225 mg providing Alpha-Casozepine

INACTIVE INGREDIENTS:
FD&C blue #1 (capsule), Hypromellose (capsule), Magnesium stearate, Maltodextrin, Titanium dioxide (capsule).


Vetoquinol Zylkene Calming Supplement, 450 mg for Large Dogs, 33-132 lbs

ACTIVE INGREDIENTS PER CAPSULE (0.470 G):
Hydrolyzed Milk Protein (Bovine): 450 mg Providing Alpha-Casozepine

INACTIVE INGREDIENTS:
Hypromellose, Magnesium Stearate, Water, FD&C Blue #1, FD&C Red #40

Vetoquinol Zylkene Plus Long-Term Calming Supplement, 225 mg for Cats and Dogs 22-65 lbs.


ACTIVE INGREDIENTS PER CAPSULE (0.748 g):

Hydrolyzed Milk Protein (Bovine): 225 mg Providing Alpha-Casozepine White Fish Muscle Hydrolysate: 90 mg

INACTIVE INGREDIENTS:
Carrageenan, FD&C Blue 1, Hypromellose, Magnesium stearate, Maltodextrin, Potassium chloride, Water, Yellow Iron Oxide.


Vetoquinol Zylkene Plus Long-Term Calming Supplement, 450 mg for Large Dogs 33-132 lbs.

ACTIVE INGREDIENTS PER CAPSULE (0.250 G):
Hydrolyzed Milk Protein (Bovine): 450 mg Providing Alpha-Casozepine

INACTIVE INGREDIENTS:
FD&C blue #1 (capsule), Hypromellose (capsule), Magnesium stearate, Maltodextrin, Titanium dioxide (capsule).

Looking Beyond July 4th?

Meet Zylkene® Plus

For pets facing ongoing stress from separation, moving, travel, household changes, new family members or other everyday stressors.

  • ✓ Daily behavioral support
  • ✓ Veterinarian recommended
  • ✓ Easy once-daily administration
  • ✓ Supports emotional well-being
Learn More →

References

  1. Horwitz. D.F. (2017) Canine and Feline Behavior. Second Edition. Wiley Blackwell.
  2. Beata, C., Beaumont-Graff, E., Diaz, C., Marion, M., Massal, N., Marlois, N., Muller, G., & Lefranc, C. (2007). Effects of alpha-casozepine (Zylkene) versus selegiline hydrochloride (Selgian, Anipryl) on anxiety disorders in dogs. Journal of Veterinary Behavior, 2(5), 175–183.
  3. Porcheron, G., Bodet, M., Poiron, K., Brault, J., Massal, N., Roy, O., & Fantini, O. (2023). Supplementation Effects of an Alpha-Casozepine and White Fish Muscle Hydrolyzed Complementary Feed on Canine Separation-Related Disorders and Quality of Life of Dogs and Their Pet Caregivers. Open Journal of Veterinary Medicine, 13(6), Article 6.

©2026 VETOQUINOL USA, Inc. VETOQUINOL and ZYLKENE are trademarks of VETOQUINOL. ThunderShirt and other brands are property of their respective owners.


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